How Abuse-Resistant are the Abuse-Deterrent Medications

Abuse-deterrent and tamper-resistant opioids: how valuable are novel formulations in thwarting non-medical use?

INTRODUCTION In recent years, attention has been given to the development of abuse-deterrent and tamper-resistant opioid formulations in light of concern over the growing misuse and abuse of opioids prescribed for the treatment of chronic pain. AREAS COVERED This critical review discusses abuse-deterrent and tamper-resistant formulations, which may help to overcome concerns of misuse in using...

Abuse-deterrent and tamper-resistant opioid formulations: what is their role in addressing prescription opioid abuse?

About one in every three individuals will experience chronic pain in their lifetime, and opioids are known to be an effective means to treat this condition. Much attention, however, has been given to the fact that prescription opioid analgesics are some of the most frequently abused drugs, and misuse is prominent in patients with chronic pain. Several new opioid formulations that are designed t...

Abuse-Deterrent Opioids — Evaluation and Labeling

Effect of abuse-deterrent formulation of OxyContin.

To the Editor: In August 2010, an abuse-deterrent formulation of the widely abused prescription opioid OxyContin was introduced. The intent was to make OxyContin more difficult to solubilize or crush, thus discouraging abuse through injection and inhalation. We examined the effect of the abuse-deterrent formulation on the abuse of OxyContin and other opioids. Data were collected quarterly from ...

Routes of Opioid Abuse and its Novel Deterrent Formulations

Despite the development and approval of abuse deterrent medications aiming to decrease the misuse of prescription opioids, abuse remains prevalent in the United States (U.S.) and abroad. Additionally, abusers have refined their tampering methods in order to bypass the advanced deterrent mechanisms of these novel formulation technologies [1,2]. Tampering with a medication can be done to assist i...